Effect of Buspirone on Blood Sugar Levels in Humans

Anxiety disorders and diabetes mellitus are one of the common psychiatric and endocrine disorders prevalent in general population, respectively1,2. The incidence and prevalence of anxiety disorders are very common in diabetic patients than in the general population3,4. In diabetic patients, recognition and control of psychiatry and anxiety symptoms are of utmost importance to increase complianc with treatment and to improve quality of life. Newer antianxiety agents of azaspirodecanedione derivatives such as buspirone, gepirone and ipsapirone are considered superior and more preferable over benzodiazepines in patients5. Buspirone lacks hypnotic, anticonvulsant, and muscle relaxant activity so termed ‘anxioselective’. The main concern about drug therapy for disorders other than diabetes is that several non-diabetic drugs may also interfere with plasma glucose and insulin level in healthy as well as diabetics6. Pharmacologically, buspirone possess its anxiolytic property because of its action as a potent partial agonist of 5hydroxytryptamine 1A (5-HT1A) receptor 7. Drugs acting through biogenic amines such as serotonin and serotonin receptor modulators viz. serotonin receptor agonists, antagonists and selective serotonin reuptake inhibitors have been demonstrated to alter the blood glucose and plasma insulin level in few experimental and clinical studies8-15. Hence, alteration in blood